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Zenpep should always be taken as prescribed by a healthcare professional. Patients currently receiving higher doses than 6,000 lipase units/kg of body weight per meal should be examined and the dosage either immediately decreased or titrated downward to a lower range.

Doses greater than 6,000 lipase units/kg of body weight per meal have been associated with colonic strictures, indicative of fibrosing colonopathy, in children with cystic fibrosis less than 12 years of age. If doses are to exceed 2,500 lipase units/kg of body weight per meal, further investigation is warranted.ĭoses greater than 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day) should be used with caution and only if they are documented to be effective by 3‑day fecal fat measures that indicate a significantly improved coefficient of fat absorption.

Changes in dosage may require an adjustment period of several days. There is great inter‑individual variation in response to enzymes thus, a range of doses is recommended. Patients should be instructed not to increase the dosage on their own. If symptoms and signs of steatorrhea persist, the dosage may be increased by a healthcare professional.

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The total daily dose should reflect approximately three meals plus two or three snacks per day.Įnzyme doses expressed as lipase units/kg of body weight per meal should be decreased in older patients because they weigh more but tend to ingest less fat per kilogram of body weight.ĭosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines.

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Usually, half of the prescribed Zenpep dose for an individualized full meal should be given with each snack. Ĭhildren Older than 12 Months and Younger than 4 YearsĮnzyme dosing should begin with 1,000 lipase units/kg of body weight per meal for children less than age 4 years to a maximum of 2,500 lipase units/kg of body weight per meal (or less than or equal to 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day.Įnzyme dosing should begin with 500 lipase units/kg of body weight per meal for those older than age 4 years to a maximum of 2,500 lipase units/kg of body weight per meal (or less than or equal to 10,000 lipase units/kg of body weight per day), or less than 4,000 lipase units/g fat ingested per day. Do not mix Zenpep capsule contents directly into formula or breast milk prior to administration. Infants may be given 3,000 lipase units (one capsule) per 120 mL of formula or breast-feeding. Patients may be dosed on a fat ingestion‑based or actual body weight‑based dosing scheme. The recommended dose of Zenpep in infants up to 12 months is 3,000 lipase units. Zenpep is available in a 3,000 lipase unit capsule.

The Conferences recommend doses of 2,000 to 4,000 lipase units in infants up to 12 months. 1, 2, 3 Zenpep should be administered in a manner consistent with the recommendations of the Conferences provided in the following paragraphs, with one exception. The dosage of Zenpep should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet (see Limitations on Dosing below).ĭosage recommendations for pancreatic enzyme replacement therapy were published following the Cystic Fibrosis Foundation Consensus Conferences. Therapy should be initiated at the lowest recommended dose and gradually increased. Zenpep is not interchangeable with other pancrelipase products. Related/similar drugs azithromycin, Zithromax, gentamicin, Creon, tobramycin, pancrelipase, pancreatin Zenpep Dosage and Administration Dosage

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